CALL FOR PAPERS Stem Cell Physiology and Pathophysiology The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects
نویسندگان
چکیده
Reza Izadpanah,* Deborah J. Schächtele,* Andreas B. Pfnür, Dong Lin, Douglas P. Slakey, Philip J. Kadowitz, and Eckhard U. Alt Applied Stem Cell Laboratory, Heart and Vascular Institute, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana; Department of Surgery, Tulane University Health Sciences Center, New Orleans, Louisiana; and Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, Louisiana
منابع مشابه
The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects.
Statins reduce atherosclerotic events and cardiovascular mortality. Their side effects include memory loss, myopathy, cataract formation, and increased risk of diabetes. As cardiovascular mortality relates to plaque instability, which depends on the integrity of the fibrous cap, we hypothesize that the inhibition of the potential of mesenchymal stem cells (MSCs) to differentiate into macrophage...
متن کاملThe Impact of Statins on Biological Characteristics of Stem Cells Provides a Novel 1 Explanation for Their Pleiotropic Beneficial and Adverse Clinical Effects
Applied Stem Cell Laboratory, Heart and Vascular Institute, Department of Medicine, Tulane 6 University Health Sciences Center; New Orleans, LA, USA. 7 Department of Surgery, Tulane University Health Sciences Center; New Orleans, LA, USA. 8 Department of Pharmacology, Tulane University Health Sciences Center; New Orleans, LA, 9 USA. 10 11 12 13 Running Head: Impact of statins on the stem cells ...
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Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...
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تاریخ انتشار 2015